Some bioidentical hormones are made by drug companies. Others, known as compounded bioidentical hormones, are custom made by a pharmacy, according to a doctor’s orders. This process is known as compounding. Compounding typically involves ingredients being combined or altered to meet the needs of an individual.
The U.S. Food and Drug Administration (FDA) has approved some forms of manufactured bioidentical hormones, including bioidentical estriol (a weak form of estrogen) and progesterone. However, the FDA hasn’t approved any custom-compounded bioidentical hormones.
Most bioidentical hormones are manufactured and sold without controls for safety, quality, or purity. Many medical organizations have taken a stand against the marketing and use of unapproved bioidentical hormones.
Compounded bioidentical hormones are often touted as being safer and more effective than synthetic hormones. But the FDA and most doctors will caution that those claims haven’t been proven in reputable studies, and that these hormones may even be potentially dangerous in some cases.